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. 1990 Jun;10(6):3268–3271. doi: 10.1128/mcb.10.6.3268

Genes transferred by retroviral vectors into normal and mutant myoblasts in primary cultures are expressed in myotubes.

B F Smith 1, R K Hoffman 1, U Giger 1, J H Wolfe 1
PMCID: PMC360696  PMID: 2160598

Abstract

Retroviral vectors were used to transfer genes efficiently into rat and dog myoblasts in primary cultures under conditions which permitted the transduced myoblasts to differentiate into myotubes expressing the transferred genes. The transduced myotubes expressed normal markers of differentiation and were morphologically indistinguishable from uninfected myotubes. Retroviral vector-mediated gene transfer was also used to correct a genetic enzyme deficiency in mutant canine muscle cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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