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. 1990 Jun;10(6):3280–3283. doi: 10.1128/mcb.10.6.3280

Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.

T O Chan 1, A Tanaka 1, J D Bjorge 1, D J Fujita 1
PMCID: PMC360699  PMID: 2160600

Abstract

Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.

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Selected References

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