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Inflammation and ASM delivery by nanocarriers coated with anti-ICAM-1 and anti-TfR. Localization ratio (LR) and specificity index (SI) of brain, lungs, and liver are shown in (A) and (B), respectively. Data are mean ± S.E.M. (n ≥ 3 mice). * compares free enzyme vs enzyme coupled to nanocarriers coated with both anti-ICAM and anti-TfR; # compares control mice vs mice pre-treated with lipopolysaccharide (LPS). *,# p < 0.05; **,## p < 0.01; ***,### p < 0.001, by Student’s t-test.
