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. 1990 Jul;10(7):3838–3842. doi: 10.1128/mcb.10.7.3838

Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene.

J Frampton 1, M Walker 1, M Plumb 1, P R Harrison 1
PMCID: PMC360852  PMID: 2355926

Abstract

A 114-base-pair promoter fragment of the human porphobilinogen deaminase gene functioned in an erythroid-specific manner in transient transfection experiments. Site-directed mutagenesis of the binding site for the erythroid-specific transcription factor (NF-E1) or an adjacent CACCC motif abolished the promoter activity. Increasing the spacing between these sites progressively reduced promoter activity, but there was no evidence that a critical alignment of the two factors on the DNA helix was required.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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