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. 1990 Aug;10(8):4424–4426. doi: 10.1128/mcb.10.8.4424

Induction of c-Ha-ras gene expression by double-stranded RNA and interferon requirement.

A Maran 1, I D Goldberg 1, B M Steinberg 1
PMCID: PMC361008  PMID: 2196455

Abstract

The addition of double-stranded RNA (dsRNA) to NIH 3T3 cells led to an increase in the RNA levels of c-Ha-ras. The double-stranded configuration was required for the increase in c-Ha-ras mRNA levels, as heat-denatured dsRNA and single-stranded RNA did not have any effect. Nuclear run-on transcription experiments indicated that the increase in c-Ha-ras mRNA levels stimulated by dsRNA was due to transcriptional activation of the gene. The induction of c-Ha-ras gene expression by dsRNA was inhibited by anti-beta interferon antibodies, suggesting that interferon might mediate the induction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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