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. 1990 Mar;10(3):1249–1253. doi: 10.1128/mcb.10.3.1249

Phosphorylation of the ETS-2 protein: regulation by the T-cell antigen receptor-CD3 complex.

S Fujiwara 1, S Koizumi 1, R J Fisher 1, N K Bhat 1, T S Papas 1
PMCID: PMC361013  PMID: 2137553

Abstract

Phosphorylation of the human ets-2 protein in response to mitogenic signals to T lymphocytes was investigated in Jurkat cells. Activation of the cells by antibodies against the T-cell antigen receptor-CD3 complex or by concanavalin A was followed within 5 min by increased phosphorylation of the protein, as shown by a mobility shift of the protein from 54 to 56 kilodaltons in sodium dodecyl sulfate-polyacrylamide gel electrophoresis and increased incorporation of 32P. The Ca2+ ionophores A23187 and ionomycin were able to mimic this effect, suggesting that this phosphorylation is mediated by Ca2+.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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