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. 1990 Mar;10(3):1259–1264. doi: 10.1128/mcb.10.3.1259

Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene.

T Matsugi 1, K Morishita 1, J N Ihle 1
PMCID: PMC361017  PMID: 2106070

Abstract

Activation of the Evi-1 zinc finger gene is a common event associated with transformation of murine myeloid leukemias. To characterize the gene product, we developed antisera against various protein domains. These antisera primarily detected a 145-kilodalton nuclear protein that bound double-stranded DNA. Binding was inhibited by chelating agents and partially restored by zinc ions.

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Selected References

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