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. 1990 Mar;10(3):1265–1269. doi: 10.1128/mcb.10.3.1265

The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.

G C Prendergast 1, L E Diamond 1, D Dahl 1, M D Cole 1
PMCID: PMC361018  PMID: 2406566

Abstract

The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.

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Selected References

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