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. 1990 Sep;10(9):4961–4966. doi: 10.1128/mcb.10.9.4961

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

L J Penn 1, M W Brooks 1, E M Laufer 1, T D Littlewood 1, J P Morgenstern 1, G I Evan 1, W M Lee 1, H Land 1
PMCID: PMC361121  PMID: 2201910

Abstract

Amino acids 106 to 143 and 354 to 433 of the human c-myc protein (439 amino acids) were shown to be required for the protein to suppress c-myc gene transcription and were found to exactly overlap with those necessary for c-myc to cooperate with ras oncogenes in the transformation of rat embryo fibroblasts. The essential carboxyl-terminal region harbors structural motifs (a basic region, a helix-loop-helix motif, and a "leucine zipper"), which, in other proteins, can mediate dimerization and sequence-specific DNA binding.

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Selected References

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