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. 1990 Sep;10(9):4990–4995. doi: 10.1128/mcb.10.9.4990

A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter.

N F Lowndes 1, P Bushel 1, L Mendelsohn 1, J Wu 1, M Y Yen 1, M Allan 1
PMCID: PMC361132  PMID: 2201911

Abstract

We have identified a short, highly repetitive element within intron -1 of the human c-Ha-ras gene. This element was found to be transcribed in both orientations and to be homologous to heterogeneous nonpolyadenylated transcripts. The repetitive element blocked transcriptional readthrough from a strong upstream viral promoter but allowed unimpaired readthrough from the c-Has-ras promoter. We suggest that it may serve to prevent excessive transcription into the coding region of the gene under such circumstances as viral insertion.

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Selected References

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