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. 1990 Sep;10(9):5002–5006. doi: 10.1128/mcb.10.9.5002

Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones.

B Turcotte 1, M E Meyer 1, M T Bocquel 1, L Bélanger 1, P Chambon 1
PMCID: PMC361135  PMID: 1697036

Abstract

Using transient transfection assays, we showed that repression of the alpha-fetoprotein promoter by intact and deletion mutants of the progesterone receptor and by chimeric progesterone/glucocorticoid-estrogen receptors in the presence of their cognate hormones was closely correlated with their ability to bind to a progesterone/glucocorticoid-responsive element. This negative regulation was also observed in the presence of antihormones, providing evidence that receptor-antihormone complexes can bind to their responsive elements in vivo.

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Selected References

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