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. 1991 Aug;11(8):3879–3885. doi: 10.1128/mcb.11.8.3879

Atypical mannolipids characterize Thy-1-negative lymphoma mutants.

P Lemansky 1, D K Gupta 1, S Meyale 1, G Tucker 1, A M Tartakoff 1
PMCID: PMC361175  PMID: 1677158

Abstract

Essentially all eukaryotic cells, including murine lymphomas, express surface proteins, such as Thy-1, which are anchored by a phosphoinositol mannolipid. Putative mannolipid anchor precursors can be detected in these cells. Six distinct Thy-1-negative lymphoma mutants lack complete mannolipids, and three mutants synthesize atypical mannolipids. The absence of complete mannolipids can account for the lack of expression of multiple mannolipid-anchored proteins and may also account for the lack of lipid anchoring in the human disease paroxysmal nocturnal hemoglobinuria. Structural information on the mannolipids of wild-type and mutant cells indicates that anchor biosynthesis in these cells may involve both transmembrane flip-flop of intermediates and a deacylation step.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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