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. 1990 Oct;10(10):5532–5535. doi: 10.1128/mcb.10.10.5532

Fos and jun cooperate in transcriptional regulation via heterologous activation domains.

C Abate 1, D Luk 1, E Gagne 1, R G Roeder 1, T Curran 1
PMCID: PMC361269  PMID: 2119000

Abstract

The products of c-fos and c-jun (Fos and Jun) function in gene regulation by interacting with the AP-1 binding site. Here we have examined the contribution of Fos and Jun toward transcriptional activity by using Fos and Jun polypeptides purified from Escherichia coli. Fos contained a transcriptional activation domain as well as a region which exerted a negative influence on transcriptional activity in vitro. Moreover, distinct activation domains in both Fos and Jun functioned cooperatively in transcriptional stimulation. Thus, regulation of gene expression by Fos and Jun results from an integration of several functional domains in a bimolecular complex.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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