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. 1990 Oct;10(10):5536–5540. doi: 10.1128/mcb.10.10.5536

Induction of the proto-oncogene c-jun by angiotensin II.

A J Naftilan 1, G K Gilliland 1, C S Eldridge 1, A S Kraft 1
PMCID: PMC361270  PMID: 2119001

Abstract

Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.

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Selected References

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