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. 1991 Oct;11(10):4839–4845. doi: 10.1128/mcb.11.10.4839

Direct-repeat analysis of chromatid interactions during intrachromosomal recombination in mouse cells.

R J Bollag 1, R M Liskay 1
PMCID: PMC361452  PMID: 1656213

Abstract

Homologous intrachromosomal recombination between linked genes can involve interactions that are either intramolecular (intrachromatid) or intermolecular (sister chromatid). To assess the relative proportions of chromatid interactions, we report studies of intrachromosomal recombination in mouse L cells containing herpes simplex virus thymidine kinase genes in two alternative configurations of direct repeats. By comparing products of reciprocal exchanges between these two configurations, we conclude that the majority of interactions that give rise to crossover products involve unequally paired sister chromatids after DNA replication. Analyses of an additional class of crossover products that involve discontinuous associated gene conversion suggest that these recombination events involve a heteroduplex DNA intermediate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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