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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Nature. 2009 Apr 23;458(7241):1056–1060. doi: 10.1038/nature07813

Figure 2. SIRT1 mediates AMPK-induced PGC-1α deacetylation.

Figure 2

(A and C) C2C12 myocytes were infected with adenoviruses encoding GFP, PGC-1α, and either control or SIRT1 shRNAs. After 8hrs (A) or 1hr (C) of AICAR treatment, PGC-1α acetylation and AMPK phosphorylation were analyzed (D-E) SIRT1+/+ and SIRT1−/− MEFs were infected with GFP and FLAG-HA-PGC-1α and treated for 8hrs (D) or 1hr (E) with AICAR to test PGC-1α acetylation and AMPK phosphorylation.

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