Table III.
Association between carcinogen-metabolizing scores and colorectal polyp risk, the TCPSa
| Carcinogen-metabolizing risk score by tertile | Control (N = 3,336) | Polyp cases | |||||||
|---|---|---|---|---|---|---|---|---|---|
| All polyps (N = 2060) | Adenoma only (N = 1160) | HPP only (N = 532) | Both (N = 368) | ||||||
| n | OR (95%CI)a | n | OR (95%CI)a | n | OR (95%CI)a | n | OR (95%CI)1 | ||
| T1 (0–9) | 1218 | 756 | 1.0 (reference) | 427 | 1.0 (reference) | 186 | 1.0 (reference) | 143 | 1.0 (reference) |
| T2(10–12) | 1775 | 1075 | 1.0 (0.9–1.1) | 611 | 1.0 (0.8–1.1) | 288 | 1.1 (0.9–1.3) | 180 | 0.8 (0.7–1.1) |
| T3(13–19) | 343 | 225 | 1.1 (0.9–1.3) | 122 | 1.1 (0.8–1.3) | 58 | 1.2 (0.9–1.6) | 45 | 1.3 (0.9–1.9) |
| Trend test | P = 0.654 | P = 0.933 | P = 0.287 | P = 0.096 | |||||
Both, synchronous adenoma and HPP.
aAdjusted for age, sex, study sites, educational attainment, alcohol consumption, BMI, physical activity, regular NSAID use, red meat intake, total energy intake, year of recruitment and recruitment before or after colonoscopy.