Skip to main content
. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Epilepsia. 2013 Feb 14;54(4):649–657. doi: 10.1111/epi.12121

Figure 6. Glo1 overexpression exacerbates seizure phenotypes.

Figure 6

a, MG concentration was measured by HPLC in the brains of FVB WT and Tg mice and is reported as relative concentration. n = 7 WT, 7 Tg. b–d, Seizures were induced in FVB WT and Tg mice with pilocarpine (300 mg/kg). n = 13 WT, 8 Tg. There was a non-significant trend for Tg mice to reach stage 4 seizures sooner than WT mice (b). Tg mice spent significantly more time in stage 4 (c) and had more severe seizures (d) than WT mice. Data are mean ± SEM. * P < 0.05 by Mann-Whitney U tests.