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. 2001 Aug 24;25(6):337–342. doi: 10.1007/s002640100271

Experimental epiphysiodesis: magnetic resonance imaging evaluation with histopathologic correlation

M Synder 1, H Harcke 2, K Conard 2, J Bowen 2
PMCID: PMC3620792  PMID: 11820437

Abstract.

We performed an experimental epiphysiodesis on the tibia in 16 immature New Zealand white rabbits. The purpose was to study the process of trauma-induced growth plate closure. The animals were killed at weekly intervals over 8 weeks. We correlated the histological findings with serial magnetic resonance images. The undamaged, central part of the growth plate became histologically abnormal within 1 week. Mature bone bridge formation in the area of the epiphysiodesis was seen after 3 to 4 weeks. The study suggests that growth arrest starts before the bone bridge formation. Factors regulating cartilage growth may also play a role.

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