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. 1990 Apr;10(4):1789–1792. doi: 10.1128/mcb.10.4.1789

Specific expression of human c-fgr in natural immunity effector cells.

K Inoue 1, T Yamamoto 1, K Toyoshima 1
PMCID: PMC362287  PMID: 2181286

Abstract

The c-fgr gene product was shown by immune complex protein kinase assay with specific antibodies to be a 58-kilodalton protein (p58c-fgr) with tyrosine-specific autophosphorylating activity. On examination of peripheral blood cells by immunoblotting with anti-c-fgr antibodies, p58c-fgr was found only in the fractions of monocytes, granulocytes, and natural killer cells. On the other hand, histochemical studies of hybridization demonstrated accumulation of c-fgr transcripts on most monocytes and large lymphocytes. In hematopoietic cell lines, p58c-fgr was detected in differentiated granulocytic cells as well as in differentiated monocytic cells of HL-60-cell origin. These data suggest a specific role for p58c-fgr in natural immunity effector cells.

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Selected References

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