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. 1990 Apr;10(4):1811–1814. doi: 10.1128/mcb.10.4.1811

Sp1 can displace GHF-1 from its distal binding site and stimulate transcription from the growth hormone gene promoter.

F P Lemaigre 1, D A Lafontaine 1, S J Courtois 1, S M Durviaux 1, G G Rousseau 1
PMCID: PMC362291  PMID: 2181288

Abstract

DNase I footprinting experiments showed that binding activities of Sp1 and of GHF-1 to its distal site on the human growth hormone gene promoter are mutually exclusive. The kinetics of GHF-1 binding were indicative of positive cooperativity. The Sp1 site did not affect promoter activity in cell-free transcription. Still, Sp1 could compensate partially for the decreased stimulation of transcription seen at low GHF-1 concentrations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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