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. 1989 Aug;9(8):3543–3547. doi: 10.1128/mcb.9.8.3543

Characterization and expression of a spliced leader RNA in the parasitic nematode Ascaris lumbricoides var. suum.

T W Nilsen 1, J Shambaugh 1, J Denker 1, G Chubb 1, C Faser 1, L Putnam 1, K Bennett 1
PMCID: PMC362403  PMID: 2796996

Abstract

The parasitic nematode Ascaris spp. contains a 22-nucleotide spliced-leader (SL) sequence identical to the trans-SL previously described in Caenorhabditis elegans and other nematodes. The SL comprises the first 22 nucleotides of a approximately 110-base RNA and is transcribed by RNA polymerase II. The SL RNA contains a trimethylguanosine cap and a consensus Sm binding site. Furthermore, the Ascaris SL RNA has the potential to adopt a secondary structure which is nearly identical to potential secondary structures of similar SL RNAs in C. elegans and Brugia malayi.

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Selected References

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