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. 1989 Aug;9(8):3557–3562. doi: 10.1128/mcb.9.8.3557

The major and minor chicken vitellogenin genes are each adjacent to partially deleted pseudogene copies of the other.

R Silva 1, A H Fischer 1, J B Burch 1
PMCID: PMC362406  PMID: 2796998

Abstract

The major chicken vitellogenin gene (VTGII) has previously been cloned and sequenced. We now report the isolation of genomic clones that encompass a minor chicken vitellogenin gene (VTGIII) which is also expressed in the liver in response to estradiol. Our analysis reveals that a pseudogene for VTGII (psi VTGII) lies 1,426 base pairs upstream of this VTGIII gene. A reevaluation of published sequence data reveals that the converse is also true, namely, that a pseudogene for VTGIII (psi VTGIII) lies 1,345 base pairs downstream of the VTGII gene. Our results show that a 335-base-pair deletion has removed the psi VTGIII promoter and cap site but left residual estrogen response element in a region where nuclease-hypersensitive sites have been reported to be induced in response to estradiol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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