The phosphorylated TDP43 pathology
of CTE and CTE-MND. (A) pTDP-43 immunostained neurites found in
periventricular region of the third ventricle in CTE II. (B) CTE stage
II demonstrating pTDP-43 immunostained neurites in a perivascular distribution.
(C) pTDP-43 immunoreactive inclusion in locus coeruleus in CTE stage
II. (D) Clusters of pTDP-43 immunoreactive neurites in the subpial
region of the brainstem in stage III CTE. (E) Perivascular pTDP-43
neurites in stage III CTE. (F) Subpial pTDP-43 neurites in the corpus
callosum of stage IV CTE. (G) Dense pTDP-43 abnormalities in the
temporal cortex of stage IV CTE-MND. (H) Dense pTDP-43 pathology of CA1
hippocampus in stage IV CTE. (I–O) (I)
perivascular focus at sulcal depth pTDP-43 abnormalities are widespread throughout
the CNS in CTE associated with MND (CTE-MND) (J, corpus callosum;
K, cerebral peduncle; L, fornix; M, subpial
region of frontal cortex; N, perivascular region frontal cortex;
O, Rolandic cortex). All images: 50-µm tissue sections, all
scale bars = 100 µm.