TABLE.
Sample Characteristics and Raw Scores of the Cognitive and Gait Measures at Baseline and 6 Months After Shunt Placementa
| Demographics | iNPH Patients, n = 12 | Control Subjects, n = 9 |
|---|---|---|
| Age at baseline, y | 74.92 (7.72) | 73.56 (9.79) |
| Symptom duration, mo | 26.96 (17.23) | N/A |
| Education, y | 14.92 (2.81) | 16.56 (1.94) |
| Sex, M/F | 4/8 | 2/7 |
| Handedness, R/L | 11/1 | 8/1 |
| Cognitive/Gait Measures | Baseline Mean (SD) | 6-mo Mean (SD) | Baseline Mean (SD) | 6-mo Mean (SD) |
|---|---|---|---|---|
| MMSE | 24.50 (5.65) | 25.58 (6.79) | 28.50 (1.60) | 29.00 (1.41) |
| Boston Naming | 47.70 (16.45) | 45.30 (21.40) | 51.57 (5.44) | 52.29 (6.78) |
| Digit Span–Total | 13.33 (3.65) | 13.83 (4.71) | 15.25 (3.33) | 16.50 (3.07) |
| Symbol Digit | 23.44 (9.63) | 32.00 (15.68) | 37.13 (10.72) | 38.13 (11.05) |
| Phonemic Fluencyb | 32.20 (15.68) | 42.50 (16.19) | 38.13 (11.05) | 46.38 (12.24) |
| Semantic Fluency | 11.45 (7.76) | 15.00 (6.66) | 16.00 (6.76) | 22.38 (15.58) |
| HVLT-R Learning | 14.82 (8.00) | 17.18 (9.02) | 20.50 (5.26) | 23.25 (7.34) |
| HVLT-R Delayed Recall | 3.09 (3.59) | 3.82 (4.07) | 6.63 (3.46) | 7.13 (3.64) |
| TMT-A | 95.56 (97.69) | 56.33 (25.88) | 33.00 (13.29) | 31.00 (10.39) |
| TMT-Bc,d | 397.44 (221.93) | 175.89 (170.24) | 92.00 (47.65) | 102.00 (54.20) |
| Line tracing timeb | 95.91 (30.27) | 80.27 (20.91) | 103.00 (31.12) | 77.25 (22.84) |
| Serial dotting time | 93.09 (59.71) | 75.00 (41.04) | 57.00 (20.60) | 48.89 (8.18) |
| Finger tapping dominant | 34.60 (13.01) | 42.67 (10.13) | 40.66 (1.91) | 41.66 (6.79) |
| Pegboard dominant | 159.41 (60.75) | 124.56 (32.89) | 108.88 (35.23) | 97.13 (23.92) |
| Gait Scaled,e,f | 21.00 (9.32) | 9.67 (6.53) | 6.00 (2.39) | 6.25 (3.28) |
a
HVLT-R, Hopkins Verbal Learning Test–Revised; iNPH, idiopathic normal pressure hydrocephalus; MMSE, Mini Mental Status Exam; TMT, Trailmaking Test.
b
Main effect of time, P < .001.
c
Group-by-time interaction, P < .003.
d
Main effect of time, P < .003.
e
Group-by-time interaction, P < .001.
f
Main effect of group P < .001.