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editorial
. 2012 Jul 27;8(8):1165–1167. doi: 10.4161/auto.20665

Table 1. Examples of model system nomenclature.

  Gene Protein
 
WT
Mutant
 
Human
ULK1
ULK1−/−
ULK1
Mouse
Ulk1
ulk1
ULK1
Rat
Ulk1
ulk1
ULK1
Chicken
ULK1
ULK1−/−
ULK1
Xenopus
ulk1
ulk1
ulk1
Zebrafish
ulk1a
ulk1a
Ulk1a
Caenorhabditis
unc-51/atg-1a
unc-51(-)b
UNC-51/ATG-1
Arabidopsis
ATG1a
atg1a
ATG1a
Yeast ATG1 atg1c Atg1

aatg-1 is an alias; however, in this case the “other name” may actually help avoid confusion by clearly identifying the gene as a homolog of ATG1. Most of the C. elegans atg genes that have non-atg designations have “other names” that incorporate the yeast ATG nomenclature. For example, lgg-1/atg-8.1 and bec-1/atg-6. We recommend that authors use both names at least for the initial time the gene is mentioned in a paper. bMutants can also be expressed by specific allele designations, as in unc-51(e369) or more generally as unc-51(lof) to indicate loss of function. cAllele designations typically take the form of the gene name followed by a dash and an allele number, as in atg1-17. This is one reason that a protein-protein interaction such as Atg12–Atg5 should not be abbreviated as "Atg12-5."