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. 1989 Oct;9(10):4581–4584. doi: 10.1128/mcb.9.10.4581

Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.

J Magram 1, K Niederreither 1, F Costantini 1
PMCID: PMC362549  PMID: 2555696

Abstract

To examine the role of human beta-globin enhancers in tissue-specific and developmental regulation, a hybrid beta-globin-simian virus 40 gene was analyzed in transgenic mice. A beta-globin DNA fragment containing two previously defined enhancers stimulated transcription from the simian virus 40 promoter in a tissue- and stage-specific pattern similar to that of the normal beta-globin gene. These results help to define the functions of beta-globin regulatory elements and suggest an approach for targeted expression of heterologous genes in erythroid cells in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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