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. 1989 Feb;9(2):820–822. doi: 10.1128/mcb.9.2.820

A yeast protein possesses the DNA-binding properties of the adenovirus major late transcription factor.

L A Chodosh 1, S Buratowski 1, P A Sharp 1
PMCID: PMC362660  PMID: 2651905

Abstract

The adenovirus major late transcription factor (MLTF), or upstream stimulatory factor, is a human promoter-specific transcription factor which recognizes the near-palindromic sequence GGCCACGTGACC (R. W. Carthew, L. A. Chodosh, and P. A. Sharp, Cell 43:439-448, 1985; L. A. Chodosh, R. W. Carthew, and P. A. Sharp, Mol. Cell. Biol. 6:4723-4733, 1986; M. Sawadogo and R. G. Roeder, Cell 43:165-175, 1985). We describe here a protein found in the yeast Saccharomyces cerevisiae which possesses DNA-binding properties that are virtually identical to those of human MLTF. These two proteins recognize the same DNA-binding site, make the same purine nucleotide contacts, and are affected in the same manner by mutations in the MLTF-binding site.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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