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. 1989 Feb;9(2):847–850. doi: 10.1128/mcb.9.2.847

Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.

M E Lambert 1, Z A Ronai 1, I B Weinstein 1, J I Garrels 1
PMCID: PMC362666  PMID: 2469006

Abstract

Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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