Table 2.
Association of inflammation related cytokines polymorphisms with changes in LFTs’ levels by consumption of silymarin
|
LFT |
Gene |
Unadjusted |
|
Adjusted |
|
|---|---|---|---|---|---|
| B (CI) | p-value | B (CI) | p-value | ||
|
AST |
TNF-α |
−4.27 (−8.57, 0.03) |
0.05 |
−4.58 (−8.97, -0.21) |
0.04* |
| TGF-β1 codon 10 |
−0.77 (−5. 17, 3.61) |
0.72 |
−0.07 (−4.56, 4.41) |
0.97 |
|
| TGF-β1 codon 25 |
2.78 (−3.36, 8.93) |
0.36 |
2.79 (−3.40, 8.98) |
0.37 |
|
| TGF-β1 codons 10/25 |
0.99 (−3.04, 5.03) |
0.62 |
1.37 (−2.73, 5.46) |
0.50 |
|
|
ALT |
TNF-α |
−8.30 (−13.73, -2.86) |
0.003* |
−8.93 (−14.62, -3.23) |
0.003* |
| TGF-β1 codon 10 |
−3.62 (−8.92, 1.67) |
0.17 |
−3.43 (−9.00, 2.14) |
0.22 |
|
| TGF-β1 codon 25 |
5.87 (−1.29, 13.03) |
0.10 |
5.94 (−1.36, 13.24) |
0.10 |
|
| TGF-β1 codons 10/25 |
−0.33 (−5.28, 4.63) |
0.89 |
0.03 (−5.11, 5.24) |
0.99 |
|
|
ALP |
TNF-α |
−6.17 (−41.08, 28.75) |
0.72 |
−0.85 (−21.93, 20.21) |
0.93 |
| TGF-β1 codon 10 |
−31.45 (−61.31, -1.59) |
0.03 |
−9.05 (−27.43, 8.32) |
0.33 |
|
| TGF-β1 codon 25 |
16.67 (−25.38, 58.73) |
0.43 |
−12.00 (−37.17, 13.17) |
0.34 |
|
| TGF-β1 codons 10/25 | −16.16 (−44.41, 12.07) | 0.25 | −8.65 (−24.63, 7.33) | 0.28 |
Multivariate regression: Parameters adjusted for age and BMI. *Significant effect. B: Partial regression coefficient.