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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Neuron. 2013 Apr 10;78(1):124–137. doi: 10.1016/j.neuron.2013.01.037

Figure 2. Inhibitory synapses onto RBC axons in the grm6-TeNT and GAD1KO retina.

Figure 2

(a) Schematic showing RBC axon terminal circuitry in wildtype and transgenic lines with suppressed glutamatergic transmission from ON-bipolar cells (grm6-TeNT) and reduced GABAergic transmission from amacrine cells (GAD1KO). (b) Immunolabeling for VIAAT (yellow) at the level of PKC positive RBC boutons (blue) in P30 wildtype, grm6-TeNT and GAD1KO retina. (c) Electron micrographs showing dyad synapses between RBC boutons (cyan) and AII (purple) and A17 (pink) amacrine cell processes in the wildtype (WT), grm6-TeNT and GAD1KO retinae at P15 and P30–35. Presynaptic ribbons are indicated by arrows. Asterisks mark examples of A17 contact. Note that RBCs in the P30 grm6-TeNT retina have multiple ribbons at a single dyad synapse.