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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Neuron. 2013 Apr 10;78(1):124–137. doi: 10.1016/j.neuron.2013.01.037

Figure 8. Summary of the alterations in RBC-A17 synapses in GABAergic transmission-defective mutants before and after eye-opening.

Figure 8

Schematic illustrating the A17-RBC synapse before and after eye-opening in the wildtype, GAD1KO and GABACKO retina. GABA and glutamate release is similar between wildtype and GABACKO (see also Eggers and Lukasiewicz, 2006a), but is altered in the GAD1KO. There is a transient upregulation of glutamate release from developing RBCs in the GAD1KO before eye-opening. However, after eye-opening, glutamate release from RBCs in the GAD1KO becomes comparable to wildtype. GABAA and not GABAC receptors are selectively reduced at maturity in the GAD1KO. This reduction of GABAA receptors on RBCs does not occur in GABAC receptor mutants.