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. 1989 Jul;9(7):3114–3116. doi: 10.1128/mcb.9.7.3114

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

L J van 't Veer 1, B M Burgering 1, R Versteeg 1, A J Boot 1, D J Ruiter 1, S Osanto 1, P I Schrier 1, J L Bos 1
PMCID: PMC362784  PMID: 2674680

Abstract

In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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