Table 2.
Allele frequencies of the A3669G SNP of GR in patients with PMF stratified according to the JAK2V617F mutation
| Patients, category | No. of cases | A/A genotype | A/G genotype | G/G genotype | No. of A alleles | No. of G alleles | Frequency of G alleles, % | P (vs local controls) | OR (95% CI) | P (vs WTCCC controls) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| JAK2V617F-positive, no. (%) | 295 | 162 (54.9) | 111 (37.6) | 22 (7.5) | 435 | 155 | 26.2 | .08 | 1.60 (1.08-2.38) | < .001 | 1.84 (1.52-2.25) |
| JAK2V617F-negative, no. (%) | 187 | 101 (54) | 71 (37.9) | 15 (8.1) | 273 | 101 | 27.0 | .07 | 1.79 (1.08-2.71) | < .001 | 1.91 (1.51-2.44) |
| JAK2V617F-positive, heterozygous, no. (%) | 175 | 100 (57.1) | 67 (38.3) | 8 (4.6) | 267 | 83 | 23.3 | .28 | 1.50 (0.98-2.30) | .01 | 1.61 (1.25-2.08) |
| JAK2V617F-positive, homozygous, no. (%) | 120 | 62 (51.7) | 44 (36.7) | 14 (11.6) | 168 | 72 | 30.0 | .61 | 2.07 (1.33-3.24) | < .001 | 2.22 (1.67-2.95) |