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. 1990 Dec;10(12):6755–6758. doi: 10.1128/mcb.10.12.6755

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells.

B R Stanton 1, S W Reid 1, L F Parada 1
PMCID: PMC362953  PMID: 1701023

Abstract

We have disrupted one allele of the N-myc locus in mouse embryonic stem (ES) cells by using homologous recombination techniques and have obtained germ line transmission of null N-myc ES cell lines with transmission of the null N-myc allele to the offspring. The creation of mice with a deficient N-myc allele will allow the generation of offspring bearing null N-myc alleles in both chromosomes and permit study of the role that this proto-oncogene plays in embryonic development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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