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Molecular and Cellular Biology logoLink to Molecular and Cellular Biology
. 1990 Dec;10(12):6759–6764. doi: 10.1128/mcb.10.12.6759

Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.

T Pace 1, M Ponzi 1, E Dore 1, C Janse 1, B Mons 1, C Frontali 1
PMCID: PMC362954  PMID: 2174115

Abstract

During prolonged in vivo mitotic multiplication of a Plasmodium berghei ANKA clone (8417HP), parasites that contained an enlarged version of chromosome 4 were observed. Restriction mapping and hybridization results demonstrated that the extra DNA present in the enlarged chromosome consists of 2.3-kb tandem repeats, known to be normally located in subtelomeric position at several chromosomal ends but absent in the original chromosome. The inserted 2.3-kb units appeared to interrupt one of the original telomeres and to create an internal (approximately 1-kb-long) telomeric sequence.

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Selected References

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