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. 1990 Dec;10(12):6813–6816. doi: 10.1128/mcb.10.12.6813

Species-specific lens activation of the thymidine kinase promoter by a single copy of the mouse alpha A-CRYBP1 site and loss of tissue specificity by multimerization.

C M Sax 1, J F Klement 1, J Piatigorsky 1
PMCID: PMC362964  PMID: 2247086

Abstract

One copy of the mouse alpha A-crystallin gene alpha A-CRYBP1 site activated the thymidine kinase (tk) promoter in a mouse lens epithelial cell line but not in primary chicken lens cells; multiple copies further activated the tk promoter and extended expression to fibroblasts, B cells, and chicken lens cultures. The loss of lens specificity by multimerization may place selective constraints on the number of alpha A-CRYBP1 sites in the alpha A-crystallin promoter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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