Table 1.
Baseline characteristics of respondents at five year follow-up by randomisation to surgical or medical management for chronic gastro-oesophageal reflux disease. Values are numbers (percentages) of participants unless stated otherwise
| Characteristic | Surgical (n=127 maximum) | Medical (n=119 maximum) | P value of difference* |
|---|---|---|---|
| Mean (SD) age in years | 48.5 (9.3) (n=127) |
46.4 (11.6) (n=119) |
0.12 |
| Sex: | |||
| Men | 79/127 (62) | 76/119 (64) | 0.79 |
| Women | 48/127 (38) | 43/119 (36) | — |
| Mean (SD) body mass index | 29.0 (4.3) (n=127) |
27.7 (3.8) (n=119) |
0.01 |
| Mean (SD) months of antireflux medication before trial entry | 57.2 (63.4) (n=124) |
46.3 (60.1) (n=117) |
0.17 |
| Erosive oesophagitis: | |||
| Yes | 63/111 (57) | 68/108 (63) | 0.35 |
| No | 48/111 (43) | 39/108 (36) | — |
| H pylori infection status: | |||
| Positive (treated) | 6/96 (6) | 10/92 (11) | 0.52 |
| Positive (untreated) | 1/96 (1) | 2/92 (2) | — |
| Negative | 55/96 (57) | 45/92 (49) | — |
| Uncertain | 34/96 (35) | 34/92 (37) | — |
| Hiatus hernia: | |||
| Yes | 73/117 (62) | 71/114 (62) | 0.99 |
| No | 44/117 (38) | 43/114 (38) | — |
| Mean (SD) questionnaire scores: | |||
| REFLUX† | 65.9 (23.7) (n=121) |
68.6 (24.0) (n=110) |
0.38 |
| EQ-5D‡ | 0.736 (0.223) (n=122) |
0.755 (0.228) (n=118) |
0.51 |
| SF-36 physical§ | 44.8 (10.0) (n=121) |
46.1 (9.1) (n=114) |
0.30 |
| SF-36 mental§ | 46.6 (11.0) (n=121) |
46.5 (11.1) (n=114) |
0.98 |
| Taking any proton pump inhibitor | 120/125 (96) | 109/118 (92) | 0.23 |
| Taking any antireflux drug | 124/125 (99) | 113/118 (96) | 0.11 |
*Using Student’s t test, χ2 test, or Fischer’s exact test as appropriate.
†REFLUX questionnaire a disease-specific measure of quality of life (score range 0–100).
‡EuroQol EQ-5D measure of health status.
§Short Form (36) Health Survey measure of health status.