Skip to main content
PMC home page
Molecular and Cellular Biology logoLink to Molecular and Cellular Biology
. 1989 May;9(5):2269–2272. doi: 10.1128/mcb.9.5.2269

c-fos proto-oncogene expression in the nervous system during mouse development.

J F Caubet 1
PMCID: PMC363028  PMID: 2501666

Abstract

I show, by in situ hybridization, that c-fos is expressed in the nervous system during mouse development. This expression was found to be restricted to specific regions at late stages of development (day 16 postcoitum), particularly to the spinal cord, dorsal root ganglia, and olfactory lobe. The c-fos protein may play a role in the maturation of these structures by activating specific genes.

Full text

PDF
2269

Images in this article

2269Image
on p.2269
2270Image
on p.2270
2271Image
on p.2271

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson D. J., Axel R. Molecular probes for the development and plasticity of neural crest derivatives. Cell. 1985 Sep;42(2):649–662. doi: 10.1016/0092-8674(85)90122-9. [DOI] [PubMed] [Google Scholar]
  2. Chowdhury K., Dressler G., Breier G., Deutsch U., Gruss P. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons. EMBO J. 1988 May;7(5):1345–1353. doi: 10.1002/j.1460-2075.1988.tb02950.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Curran T., Morgan J. I. Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science. 1985 Sep 20;229(4719):1265–1268. doi: 10.1126/science.4035354. [DOI] [PubMed] [Google Scholar]
  4. De Togni P., Niman H., Raymond V., Sawchenko P., Verma I. M. Detection of fos protein during osteogenesis by monoclonal antibodies. Mol Cell Biol. 1988 May;8(5):2251–2256. doi: 10.1128/mcb.8.5.2251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Desplan C., Theis J., O'Farrell P. H. The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature. 1985 Dec 19;318(6047):630–635. doi: 10.1038/318630a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dony C., Gruss P. Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal web tissue. Nature. 1987 Aug 20;328(6132):711–714. doi: 10.1038/328711a0. [DOI] [PubMed] [Google Scholar]
  7. Dragunow M., Peterson M. R., Robertson H. A. Presence of c-fos-like immunoreactivity in the adult rat brain. Eur J Pharmacol. 1987 Mar 3;135(1):113–114. doi: 10.1016/0014-2999(87)90767-9. [DOI] [PubMed] [Google Scholar]
  8. Dragunow M., Robertson H. A. Generalized seizures induce c-fos protein(s) in mammalian neurons. Neurosci Lett. 1987 Nov 23;82(2):157–161. doi: 10.1016/0304-3940(87)90121-2. [DOI] [PubMed] [Google Scholar]
  9. Dragunow M., Robertson H. A. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus. Nature. 1987 Oct 1;329(6138):441–442. doi: 10.1038/329441a0. [DOI] [PubMed] [Google Scholar]
  10. Dragunow M., Robertson H. A. Localization and induction of c-fos protein-like immunoreactive material in the nuclei of adult mammalian neurons. Brain Res. 1988 Feb 9;440(2):252–260. doi: 10.1016/0006-8993(88)90993-6. [DOI] [PubMed] [Google Scholar]
  11. Enderlin S., Norman A. W., Celio M. R. Ontogeny of the calcium binding protein calbindin D-28k in the rat nervous system. Anat Embryol (Berl) 1987;177(1):15–28. doi: 10.1007/BF00325286. [DOI] [PubMed] [Google Scholar]
  12. Franza B. R., Jr, Rauscher F. J., 3rd, Josephs S. F., Curran T. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science. 1988 Mar 4;239(4844):1150–1153. doi: 10.1126/science.2964084. [DOI] [PubMed] [Google Scholar]
  13. Goelet P., Castellucci V. F., Schacher S., Kandel E. R. The long and the short of long-term memory--a molecular framework. 1986 Jul 31-Aug 6Nature. 322(6078):419–422. doi: 10.1038/322419a0. [DOI] [PubMed] [Google Scholar]
  14. Greenberg M. E., Ziff E. B., Greene L. A. Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science. 1986 Oct 3;234(4772):80–83. doi: 10.1126/science.3749894. [DOI] [PubMed] [Google Scholar]
  15. Greenberg M. E., Ziff E. B. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature. 1984 Oct 4;311(5985):433–438. doi: 10.1038/311433a0. [DOI] [PubMed] [Google Scholar]
  16. Hiromi Y., Kuroiwa A., Gehring W. J. Control elements of the Drosophila segmentation gene fushi tarazu. Cell. 1985 Dec;43(3 Pt 2):603–613. doi: 10.1016/0092-8674(85)90232-6. [DOI] [PubMed] [Google Scholar]
  17. Hunt S. P., Pini A., Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature. 1987 Aug 13;328(6131):632–634. doi: 10.1038/328632a0. [DOI] [PubMed] [Google Scholar]
  18. Kruijer W., Schubert D., Verma I. M. Induction of the proto-oncogene fos by nerve growth factor. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7330–7334. doi: 10.1073/pnas.82.21.7330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Morgan J. I., Cohen D. R., Hempstead J. L., Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science. 1987 Jul 10;237(4811):192–197. doi: 10.1126/science.3037702. [DOI] [PubMed] [Google Scholar]
  20. Morgan J. I., Curran T. Role of ion flux in the control of c-fos expression. Nature. 1986 Aug 7;322(6079):552–555. doi: 10.1038/322552a0. [DOI] [PubMed] [Google Scholar]
  21. Morle F., Starck J., Godet J. Alpha-thalassemia due to the deletion of nucleotides -2 and -3 preceding the AUG initiation codon affects translation efficiency both in vitro and in vivo. Nucleic Acids Res. 1986 Apr 25;14(8):3279–3292. doi: 10.1093/nar/14.8.3279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Müller R., Bravo R., Burckhardt J., Curran T. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature. 1984 Dec 20;312(5996):716–720. doi: 10.1038/312716a0. [DOI] [PubMed] [Google Scholar]
  23. Rauscher F. J., 3rd, Cohen D. R., Curran T., Bos T. J., Vogt P. K., Bohmann D., Tjian R., Franza B. R., Jr Fos-associated protein p39 is the product of the jun proto-oncogene. Science. 1988 May 20;240(4855):1010–1016. doi: 10.1126/science.3130660. [DOI] [PubMed] [Google Scholar]
  24. Rauscher F. J., 3rd, Sambucetti L. C., Curran T., Distel R. J., Spiegelman B. M. Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell. 1988 Feb 12;52(3):471–480. doi: 10.1016/s0092-8674(88)80039-4. [DOI] [PubMed] [Google Scholar]
  25. Renz M., Neuberg M., Kurz C., Bravo R., Müller R. Regulation of c-fos transcription in mouse fibroblasts: identification of DNase I-hypersensitive sites and regulatory upstream sequences. EMBO J. 1985 Dec 30;4(13B):3711–3716. doi: 10.1002/j.1460-2075.1985.tb04139.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Renz M., Verrier B., Kurz C., Müller R. Chromatin association and DNA binding properties of the c-fos proto-oncogene product. Nucleic Acids Res. 1987 Jan 12;15(1):277–292. doi: 10.1093/nar/15.1.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sagar S. M., Sharp F. R., Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science. 1988 Jun 3;240(4857):1328–1331. doi: 10.1126/science.3131879. [DOI] [PubMed] [Google Scholar]
  28. Sambucetti L. C., Curran T. The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose. Science. 1986 Dec 12;234(4782):1417–1419. doi: 10.1126/science.3491427. [DOI] [PubMed] [Google Scholar]
  29. Sandberg M., Vuorio T., Hirvonen H., Alitalo K., Vuorio E. Enhanced expression of TGF-beta and c-fos mRNAs in the growth plates of developing human long bones. Development. 1988 Mar;102(3):461–470. doi: 10.1242/dev.102.3.461. [DOI] [PubMed] [Google Scholar]
  30. Schulze F., Chowdhury K., Zimmer A., Drescher U., Gruss P. The murine homeo box gene product, Hox 1.1 protein, is growth-controlled and associated with chromatin. Differentiation. 1987;36(2):130–137. doi: 10.1111/j.1432-0436.1987.tb00187.x. [DOI] [PubMed] [Google Scholar]
  31. Stanton L. W., Fahrlander P. D., Tesser P. M., Marcu K. B. Nucleotide sequence comparison of normal and translocated murine c-myc genes. Nature. 1984 Aug 2;310(5976):423–425. doi: 10.1038/310423a0. [DOI] [PubMed] [Google Scholar]
  32. Sukhatme V. P., Cao X. M., Chang L. C., Tsai-Morris C. H., Stamenkovich D., Ferreira P. C., Cohen D. R., Edwards S. A., Shows T. B., Curran T. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988 Apr 8;53(1):37–43. doi: 10.1016/0092-8674(88)90485-0. [DOI] [PubMed] [Google Scholar]
  33. Verma I. M., Graham W. R. The fos oncogene. Adv Cancer Res. 1987;49:29–52. doi: 10.1016/s0065-230x(08)60793-9. [DOI] [PubMed] [Google Scholar]

Articles from Molecular and Cellular Biology are provided here courtesy of Taylor & Francis

RESOURCES