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. 1988 Jan;8(1):433–440. doi: 10.1128/mcb.8.1.433

Human hTM alpha gene: expression in muscle and nonmuscle tissue.

A R MacLeod 1, C Gooding 1
PMCID: PMC363144  PMID: 3336363

Abstract

We have isolated a cDNA clone from a human skeletal muscle library which contains the complete protein-coding sequence of a skeletal muscle alpha-tropomyosin. This cDNA sequence defines a fourth human tropomyosin gene, the hTM alpha gene, which is distinct from the hTMnm gene encoding a closely related isoform of skeletal muscle alpha-tropomyosin. In cultured human fibroblasts, the hTM alpha gene encodes both skeletal-muscle- and smooth-muscle-type alpha-tropomyosins by using an alternative mRNA-splicing mechanism.

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Selected References

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