Table 3. Optical Coherence Tomography Changes Corresponding with Clinically Significant Impairment of Vision and Vision-Specific Quality of Life in Multiple Sclerosis (n = 122, 239 eyes).

	Macular RNFL Thickness	GCL+IPL Thickness	Macular RNFL+GCL+IPL Thickness	OPL+INL Thickness	ONL+PRL Thickness	Peripapillary RNFL Thickness
VA (μm per line [5 letters] of acuity)	1.3	1.3	2.7	−0.6	−0.3	2.2
P	<0.001	0.001	<0.001	0.002	0.25	<0.001
2.5% LCLA (μm per 7 letters of acuity)	1.9	1.9	3.8	−0.7	−0.8	3.3
P	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
1.25% LCLA (μm per 7 letters of acuity)	1.9	2.4	4.3	−0.5	−0.9	3.3
P	<0.001	<0.001	<0.001	0.01	0.01	<0.001
NEI-VFQ-25 composite score (μm per 5 points)	0.7	0.9	1.6	0.02	−0.2	1.0
P	0.006	<0.001	<0.001	0.89	0.50	0.03
10-item supplement composite score (μm per 5 points)	0.8	1.0	1.7	0.04	−0.2	1.0
P	0.002	<0.001	<0.001	0.78	0.44	0.05
Peripapillary RNFL loss (μm per 10am RNFL)	3.4	4.2	7.6	−0.26	−0.12	—
P	<0.001	<0.001	<0.001	0.31	0.69

GCL = ganglion cell layer; INL = inner nuclear layer; IPL = inner plexiform layer; LCLA = low contrast letter acuity; NEI-VFQ-25 = National Eye Institute Visual Function Questionnaire; ONL = outer nuclear layer; OPL = outer plexiform layer; PRL = photoreceptor layer; RNFL = retinal nerve fiber layer; VA = visual acuity.

^*Letters seen correctly on Early Treatment Diabetic Retinopathy Study charts at 3.2 m.

^†Letters seen correctly on Sloan LCLA charts at 2.0 m.

P-values reflect generalized estimating equation models accounting for age and within-patient intereye correlations.