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. 1988 Feb;8(2):515–521. doi: 10.1128/mcb.8.2.515

Swiveling and decatenation of replicating simian virus 40 genomes in vivo.

R M Snapka 1, M A Powelson 1, J M Strayer 1
PMCID: PMC363175  PMID: 2832724

Abstract

We have found that type II topoisomerase inhibitors have two effects on replicating simian virus 40 genomes in vivo: production of catenated dimers and slowed replication of the last 5% of the genome. This suggests that type II topoisomerase simultaneously decatenates and facilitates replication fork movement at this stage of DNA replication. On the basis of this observation, a detailed model is proposed for the roles of topoisomerases I and II in simian virus 40 DNA replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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