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. 1988 Feb;8(2):1006–1009. doi: 10.1128/mcb.8.2.1006

Expression of the rat myosin light-chain 2 gene in transgenic mice: stage specificity, developmental regulation, and interrelation with the endogenous gene.

M Shani 1, I Dekel 1, O Yoffe 1
PMCID: PMC363237  PMID: 2451118

Abstract

The expression of the rat skeletal myosin light-chain 2 gene in two transgenic strains was tissue specific and stage specific. However, the temporal regulation during development of the transgene was different from that of the endogenous gene. Surprisingly, in one strain, the expression of the transgene was associated with a significant down-regulation of the endogenous gene. The possible mechanisms to account for the suppression of the endogenous gene and the potential implications of this suppression are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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