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. 1988 Apr;8(4):1677–1683. doi: 10.1128/mcb.8.4.1677

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

C J Thiele 1, P S Cohen 1, M A Israel 1
PMCID: PMC363328  PMID: 3380093

Abstract

We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.

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