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. 1988 May;8(5):2247–2250. doi: 10.1128/mcb.8.5.2247

Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C.

K D Rodland 1, L L Muldoon 1, T H Dinh 1, B E Magun 1
PMCID: PMC363411  PMID: 3260332

Abstract

A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation. Following TPA-induced depletion of protein kinase C activity, EGF stimulation of VL30 transcription and accumulation was unaffected while TPA effects were inhibited, implying that EGF and TPA act by separable pathways.

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Selected References

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