Table 2. Quantitation of chromosomal abnormalities in metaphase spreads from three independently derived cancer cell lines from Sprr2f-Cre; Pot1a^L/L; p53^L/L mice.

	# Metaphase anomalies	% Normal metaphase	% Aberration metaphases	% Cells w/breaks	% Cells w/fusions	Fusion/metaphase	% Poly/tetraploid	c-anaphase
#1	45	15.5	20	4.4	13.3	0.18	66.7	15.5
#2	36	13.9	22.2	5.5	19.4	0.25	77.8	2.8
#3	32	0	100	12.5	100	3.9	84.4	0

The data reveal that most cells harbor significant abnormalities.