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. 1989 Dec;9(12):5722–5725. doi: 10.1128/mcb.9.12.5722

The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family.

T Pawson 1, K Letwin 1, T Lee 1, Q L Hao 1, N Heisterkamp 1, J Groffen 1
PMCID: PMC363745  PMID: 2685575

Abstract

We have recently isolated human and rat cDNAs (designated FER and flk, respectively) which encode nonreceptor protein-tyrosine kinases which are very similar to one another and related in sequence and domain structure to the c-fps/fes gene product. We show that FER and flk are human and rat counterparts of an evolutionarily conserved gene, hereafter termed FER regardless of species. The human and rat FER genes encode a widely expressed 94-kilodalton protein-tyrosine kinase which is antigenically related to the fps/fes protein-tyrosine kinase. The structural and antigenic similarities between the FER and fps/fes proteins suggest that they are members of a new family of nonreceptor protein-tyrosine kinases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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