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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: ChemMedChem. 2013 Jan 29;8(3):385–395. doi: 10.1002/cmdc.201200585

Table 2.

Inhibition of binding of [3H]baclofen to GABAB receptors (cat cerebellum) and [3H]muscimol to GABAA receptors (rat cortex).[16]

graphic file with name nihms-455683-t0018.jpg
Compd R IC50 [μm]
GABAB GABAA
GABA (5) – 0.025 0.128
9 H 0.0024 1.7
10 Me 0.0066 inactive