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. 1992 Jan;12(1):302–308. doi: 10.1128/mcb.12.1.302

Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals.

M T Diaz-Meco 1, I Dominguez 1, L Sanz 1, M M Municio 1, E Berra 1, M E Cornet 1, A Garcia de Herreros 1, T Johansen 1, J Moscat 1
PMCID: PMC364110  PMID: 1309592

Abstract

Cell growth and tumor transformation can be restrained in certain cell systems by the action of transforming growth factor beta (TGF-beta). It has been established that the mechanism whereby TGF-beta 1 inhibits cell growth does not interfere with the triggering of early mitogenic signal transduction mechanisms. Phospholipase C-catalyzed hydrolysis of phosphatidylcholine (PC) is a relatively late step in the cascade activated by growth factors. Therefore, conceivably activation of phospholipase C-catalyzed hydrolysis of PC could be the target of TGF-beta 1 action. In the study reported here, we demonstrate that TGF-beta 1 inhibits the coupling of ras p21 to the activation of PC hydrolysis, which appears to be critical for the antiproliferative effects of TGF-beta 1.

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Selected References

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