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(a) Transmitted light and laser scanning confocal (overlay) micrographs depicting blank and drug loaded double-walled PLLA(PLGA) microspheres. The distribution of Dox in formulations B and D microspheres is indicated in green. The distribution of chi-p53 nanoparticles in formulations C and D microspheres is indicated in red and yellow (colocalization of red and green), respectively. Scale bar = 50 μm. (b) In vitro Dox and chi-p53 release from double-walled PLLA(PLGA) microspheres.
